Subsequent studies included using 3X daily from mating to one week before weaning and demonstrated no effects on the pregnant females or their litters. The product is normally intended for once-a-month administration only. These effects were directly attributable to the exaggerated experimental dosing regimen. Puppies nursing these females which received exaggerated dosing regimens demonstrated milbemycin-related effects. Safety studies in pregnant dogs demonstrated that high doses (1.5 mg/kg = 3X) of milbemycin oxime given in an exaggerated dosing regimen (daily from mating through weaning), resulted in measurable concentrations of the drug in milk. Two studies in heartworm-infected dogs were conducted which demonstrated mild, transient hypersensitivity reactions in treated dogs with high microfilaremia counts (see Precautions for reactions observed). Milbemycin oxime was used safely in animals receiving frequently used veterinary products such as vaccines, anthelmintics, antibiotics, steroids, flea collars, shampoos and dips. In well-controlled clinical field studies 786 dogs completed treatment with milbemycin oxime. Milbemycin oxime has been tested safely in over 75 different breeds of dogs, including collies, pregnant females, breeding males and females, and puppies over two weeks of age. The temporary use of an adulticide product may be necessary to kill these adult fleas.

These adult fleas are unable to produce viable offspring. If a SENTINEL FLAVOR TABS-treated dog comes in contact with a flea-infested environment, adult fleas may infest the treated animal. The concurrent use of an approved adulticide may be employed depending on the severity of the infestation. Cooler geographic areas may have longer lag periods due to a prolonged flea life cycle. Therefore, noticeable control may not be observed until several weeks after dosing when a preexisting infestation is present. Based on results of clinical studies, this emergence generally occurs during the first 30-60 days. However, preexisting flea populations may continue to develop and emerge after treatment with SENTINEL FLAVOR TABS has begun. SENTINEL FLAVOR TABS immediately break the flea life cycle by inhibiting egg development. These reactions are presumably caused by release of protein from dead or dying microfilariae.

Mild, transient hypersensitivity reactions manifested as labored respiration, vomiting, salivation and lethargy have been noted in some treated dogs carrying a high number of circulating microfilariae. Infected dogs should be treated to remove adult heartworms and microfilariae prior to initiating treatment with SENTINEL FLAVOR TABS. Prior to administration of SENTINEL FLAVOR TABS, dogs should be tested for existing heartworm infections. (See Efficacy).ĭo not use in puppies less than four weeks of age and less than two pounds of body weight. Lufenuron prevents most flea eggs from hatching or maturing into adults and thus prevents and controls flea populations by breaking the life cycle. After biting a lufenuron-treated dog, the female flea ingests a blood meal containing lufenuron which is subsequently deposited in her eggs. Lufenuron has no effect on the adult flea. Lufenuron's mode of action is interference with chitin synthesis, polymerization and deposition. Lufenuron, the other active ingredient in SENTINEL FLAVOR TABS, is an insect development inhibitor which breaks the flea life cycle by inhibiting egg development. Milbemycin oxime eliminates the tissue stage of heartworm larvae and the adult stage of hookworm ( Ancylostoma caninum), roundworm ( Toxocara canis and Toxascaris leonina) and whipworm ( Trichuris vulpis) infestations when administered orally according to the recommended dosage schedule. Milbemycin oxime, one active ingredient in SENTINEL FLAVOR TABS, is a macrocyclic anthelmintic which is believed to act by interfering with invertebrate neurotransmission.

Sentinel heartworm treatment